Regulation of Phospholipase D in L6 Skeletal Muscle Myoblasts
نویسندگان
چکیده
منابع مشابه
Vasopressin stimulates phospholipase D, protein synthesis and RNA accretion in L6 myoblasts.
A cyclo-oxygenase metabolite of arachidonic acid, prostaglandin F, appears to be closely involved in the stimulation of protein synthesis by insulin in skeletal muscle [l] and in L6 myoblasts [2]. At present, however, it is not clear if the cyclo-oxygenase pathway is the only route leading to increased protein synthesis in skeletal muscle. In 3T3 fibroblasts, exogenous diacylglycerol has been s...
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Shah, O. Jameel, Scot R. Kimball, and Leonard S. Jefferson. Glucocorticoids abate p70 and eIF4E function in L6 skeletal myoblasts. Am J Physiol Endocrinol Metab 279: E74–E82, 2000.—The catabolic properties of glucocorticoid hormones are largely attributable to dual regulation of protein degradation and synthesis. With regard to the latter, glucocorticoids modulate the translational machinery, n...
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Efflux of 3 G C1 ions was followed in undifferentiated L6 myoblasts at rest and after exposure to hypotonic saline in order to test participation of the chloride exit in regulatory volume decrease mechanism. The efflux curve can be fitted at least with two t ime constants. After the hypotonic stress the slow rate constant increases almost threefold, from 0.021 ±0.019 m i n 1 normal saline to 0....
متن کاملInhibitors of phospholipase A2 block the stimulation of protein synthesis by insulin in L6 myoblasts.
Insulin at a concentration close to the physiological range (100 mu-units/ml) stimulated protein synthesis in L6 myoblasts by 17%. Pre-treatment with the phospholipase A2 inhibitors mepacrine or dexamethasone prevented this stimulation and decreased the release of prostaglandin F2 alpha, implicating the action of phospholipase A2 and the subsequent metabolism of arachidonic acid to prostaglandi...
متن کاملMaxi chloride channels in L6 myoblasts.
The existence of a large conductance voltage sensitive chloride channel is documented in undifferentiated cells (myoblasts) of the L6 rat muscle cell line. At this stage of development the resting membrane conductance is dominated by potassium ions only (Kidokoro 1975). The conductance of the channel in symmetrical 120 mmol/l choline chloride is 331 +/- 4 pS. The probability of the channel bein...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.16.10910